Or at least that what Destin of Smarter Every Day believes after he frustratingly tried to get it going himself.
See, the “backwards brain bicycle” was mechanically tweaked to turn left when you turn right, and vice versa. He thought it would be easy to ride, since he had the knowledge of how it worked. What he didn't have was the understanding of how to ride it, causing him some deep frustration.
Can he wrap his head around how to ride it properly?
Watch and learn:
via io9
The closest real-life analogy I can think of in my own experience is roller skating. I was pretty good at it when I was young. Then I didn't skate for twenty years, just walked. When I took it up again to skate with my kids, it took a good twenty minutes to realign my reflexes (which was quite comical), then suddenly I was as good as I ever was.
I'd try modifying the reverse-geared bike with drop/racing handlebars, painted a unique color, hornless seat, streamers, etc. In fact starting with a recumbent bike would probably work pretty well. Alternatively, you could (probably) manage it by only ever riding your reverse-geared bike on one or two certain road/trail/paths, and NEVER riding a regular bicycle down those same locations. If they are sufficiently obviously different than each other, you won't get confused.